Spectra of axions emitted from main sequence stars

We compute the detailed energy spectra of axions with two-photon coupling produced in stellar cores over a wide range of stellar masses. We focus on main sequence stars and base our calculations on the stellar interior profiles from MESA, for which we provide simple fits in an appendix. The obtained stellar axion spectra, combined with recent models of star formation history and stellar initial mass function, enable us to estimate the properties of the diffuse axion background sourced by all the stars in the universe. The fluxes of this stellar axion background and its decay photons are subdominant to but can in principle be disentangled from those expected from the Sun and the early universe based on their different spectral and spatial profiles

A lunar space station

A concept for a space station to be placed in low lunar orbit in support of the eventual establishment of a permanent moon base is proposed. This space station would have several functions: (1) a complete support facility for the maintenance of the permanent moon base and its population; (2) an orbital docking area to facilitate the ferrying of materials and personnel to and from Earth; (3) a zero gravity factory using lunar raw materials to grow superior GaAs crystals for use in semiconductors and mass produce inexpensive fiber glass; and (4) a space garden for the benefit of the air food cycles. The mission scenario, design requirements, and technology needs and developments are included as part of the proposal

On the Frequency Dependency of Radio Channel's Delay Spread: Analyses and Findings From mmMAGIC Multi-frequency Channel Sounding

This paper analyzes the frequency dependency of the radio propagation channel's root mean square (rms) delay spread (DS), based on the multi-frequency measurement campaigns in the mmMAGIC project. The campaigns cover indoor, outdoor, and outdoor-to-indoor (O2I) scenarios and a wide frequency range from 2 to 86 GHz. Several requirements have been identified that define the parameters which need to be aligned in order to make a reasonable comparison among the different channel sounders employed for this study. A new modelling approach enabling the evaluation of the statistical significance of the model parameters from different measurements and the establishment of a unified model is proposed. After careful analysis, the conclusion is that any frequency trend of the DS is small considering its confidence intervals. There is statistically significant difference from the 3GPP New Radio (NR) model TR 38.901, except for the O2I scenario.Comment: This paper has been accepted to the 2018 12th European Conference on Antennas and Propagation (EuCAP), London, UK, April 201

Multiscale identification of the random elasticity field at mesoscale of a heterogeneous microstructure using multiscale experimental observations

International audienceThis paper deals with a multiscale statistical inverse method for performing the experimental identification of the elastic properties of materials at macroscale and at mesoscale within the framework of a heterogeneous microstructure which is modeled by a random elastic media. New methods are required for carrying out such multiscale identification using experimental measurements of the displacement fields carried out at macroscale and at mesoscale with only a single specimen submitted to a given external load at macroscale. In this paper, for a heterogeneous microstructure, a new identification method is presented and formulated within the framework of the three-dimensional linear elasticity. It permits the identification of the effective elasticity tensor at macroscale, and the identification of the tensor-valued random field, which models the apparent elasticity field at mesoscale. A validation is presented first with simulated experiments using a numerical model based on the hypothesis of 2D-plane stresses. Then, we present the results given by the proposed identification procedure for experimental measurements obtained by digital image correlation (DIC) on cortical bone

De novo design of bioactive protein switches.

Allosteric regulation of protein function is widespread in biology, but is challenging for de novo protein design as it requires the explicit design of multiple states with comparable free energies. Here we explore the possibility of designing switchable protein systems de novo, through the modulation of competing inter- and intramolecular interactions. We design a static, five-helix 'cage' with a single interface that can interact either intramolecularly with a terminal 'latch' helix or intermolecularly with a peptide 'key'. Encoded on the latch are functional motifs for binding, degradation or nuclear export that function only when the key displaces the latch from the cage. We describe orthogonal cage-key systems that function in vitro, in yeast and in mammalian cells with up to 40-fold activation of function by key. The ability to design switchable protein functions that are controlled by induced conformational change is a milestone for de novo protein design, and opens up new avenues for synthetic biology and cell engineering

Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis, combining global occupancy of Lsd1, genome-wide analysis of its substrates H3K4 monomethylation and dimethylation, and gene expression profiling, reveals that Lsd1 represses hematopoietic stem and progenitor cell (HSPC) gene expression programs during hematopoietic differentiation. We found that Lsd1 acts at transcription start sites, as well as enhancer regions. Loss of Lsd1 was associated with increased H3K4me1 and H3K4me2 methylation on HSPC genes and gene derepression. Failure to fully silence HSPC genes compromised differentiation of hematopoietic stem cells as well as mature blood cell lineages. Collectively, our data indicate that Lsd1-mediated concurrent repression of enhancer and promoter activity of stem and progenitor cell genes is a pivotal epigenetic mechanism required for proper hematopoietic maturation. DOI: http://dx.doi.org/10.7554/eLife.00633.00

Forager and farmer evolutionary adaptations to malaria evidenced by 7000 years of thalassemia in Southeast Asia

Thalassemias are inherited blood disorders that are found in high prevalences in the Mediterranean, Southeast Asia and the Pacific. These diseases provide varying levels of resistance to malaria and are proposed to have emerged as an adaptive response to malaria in these regions. The transition to agriculture in the Holocene has been suggested to have influenced the selection for thalassemia in the Mediterranean as land clearance for farming encouraged interaction between Anopheles mosquitos, the vectors for malaria, and human groups. Here we document macroscopic and microscopic skeletal evidence for the presence of thalassemia in both hunter-gatherer (Con Co Ngua) and early agricultural (Man Bac) populations in northern Vietnam. Firstly, our findings demonstrate that thalassemia emerged prior to the transition to agriculture in Mainland Southeast Asia, from at least the early seventh millennium BP, contradicting a long-held assumption that agriculture was the main driver for an increase in malaria in Southeast Asia. Secondly, we describe evidence for significant malarial burden in the region during early agriculture. We argue that the introduction of farming into the region was not the initial driver of the selection for thalassemia, as it may have been in other regions of the world

Pattern formation in directional solidification under shear flow. I: Linear stability analysis and basic patterns

An asymptotic interface equation for directional solidification near the absolute stabiliy limit is extended by a nonlocal term describing a shear flow parallel to the interface. In the long-wave limit considered, the flow acts destabilizing on a planar interface. Moreover, linear stability analysis suggests that the morphology diagram is modified by the flow near the onset of the Mullins-Sekerka instability. Via numerical analysis, the bifurcation structure of the system is shown to change. Besides the known hexagonal cells, structures consisting of stripes arise. Due to its symmetry-breaking properties, the flow term induces a lateral drift of the whole pattern, once the instability has become active. The drift velocity is measured numerically and described analytically in the framework of a linear analysis. At large flow strength, the linear description breaks down, which is accompanied by a transition to flow-dominated morphologies, described in a companion paper. Small and intermediate flows lead to increased order in the lattice structure of the pattern, facilitating the elimination of defects. Locally oscillating structures appear closer to the instability threshold with flow than without.Comment: 20 pages, Latex, accepted for Physical Review